The NMN (nicotinamide mononucleotide) is among the top studied and well-known substances for slowing the process of aging.
NMN is a chemical which naturally occurs in our body.
NMN can be viewed as a precursor for NAD+. NAD+ is an vital molecule that is found in every cell within our body.
NAD+ is a chemical that many proteins and enzymes require to perform their functions.
For instance, NAD+ is required for the proper maintenance and repair of our epigenome and DNA (by enzymes such as sirtuins and PARPs).
What are the consequences of NMN?
1. NMN boosts the energy levels
Most often, people claim that they feel more energetic when they consume NMN supplements.
In order to boost your energy levels, you should consume a sufficient amount of.
Certain people have already experienced the effects of the dose of 250 mg of NNM and others need to take at minimum 500 mg.
Research has shown that when administered orally NMN enhances stamina and endurance in mice who are old, by as much as 80 percent.
2. NMN enhances memory
The majority of people who utilize NMN have improved cognitive functioning, which can make people feel more sharp or at concentrating.
There are also studies that show that NMN can have beneficial effects on brain function, such as increasing cognition and blood flow to the mice’s brains.
The brain’s blood flow is restored in old mice that take NMN at the same levels as mice in their youth. The mice that are red have no NMN.
Source: Nicotinamide Mononucleotide (NMN) supplementation helps to restore neurovascular and cerebromicrovascular coupling responses , and improves cognitive performance in mice that are old. Redox Biology, 2019
3. NMN & healthier blood vessels
Research has shown that NMN revitalizes the blood vessels of old age. NMN significantly enhances, for instance the elasticity of blood vessels in elderly animals.
Old mice who get NMN contain blood vessels that expand just as much as young control mice as well as young mice who receive NMN. The dilation of blood vessels was significantly reduced in older mice who were not receiving NMN.
Source Nicotinamide Mononucleotide Supplementation reduces the effects of oxidative stress and vascular dysfunction as mice age. Aging Cell, 2016
Furthermore, the mitochondria within the cells of blood vessels (endothelial cells) are healthier after NMN. Mitochondria are the energy sources of cells.
4. NMN enhances metabolism
This is crucial as the metabolism is reduced dramatically which can result in an increase likelihood of developing various diseases.
Research has shown that NMN is able to reduce insulin resistance, enhance the lipid profile of plasma and help reduce the weight gain associated with aging increase, while also increasing physical fitness.
5. NMN helps reverse decline due to aging in older organisms
As we age the following things begin to decline such as our eyesight endurance, stamina levels as well as bone density, energy levels and immune system. These all improve as per studies on mice that are old.
6. NMN improves fertility
A few people who use NMN claim to experience an increase in their libido.
Biotech companies have found they NMN or NMN derivatives can help make animals that are old fertile once more.
7. NMN helps improve the health of stem cells
When we age, stem cells decrease and the remaining stem cells tend to become deficient. This can lead to aging because stem cells create new cells and help maintain our tissues. Different studies demonstrate that NMN and raising NAD levels, can help improve the health of stem cells and improve self-renewal.
8. NMN repairs DNA damage
NMN helps cells repair damaged DNA. DNA damage is among the main reasons we grow older.
Mice treated with NMN were significantly less prone to DNA damage (as determined by alpha-H2AX an indicator of DNA damages).
Other studies also show positive effects of NMN in reducing aging and sometimes even reverse specific age-related conditions in older animals back to a healthier condition.